| 1 | The Last Lecture. Randy Pausch with Jeffrey Zaslow. Hyperion, $21.95 ISBN 978-1-4013-2325-7 | 1 | 37 |
| 2 | Outliers. Malcolm Gladwell. Little, Brown, $27.99 ISBN 978-0-316-01792-3 | 3 | 5 |
| 3 | Dewey. Vicki Myron with Bret Witter. Grand Central, $19.99 ISBN 978-0-446-40741-0 | 2 | 13 |
| 4 | American Lion. Jon Meacham. Random House, $30 ISBN 978-1-4000-6325-3 | 4 | 6 |
| 5 | The Purpose of Christmas. Rick Warren. Howard Books, $17.99 ISBN 978-1-4165-5900-9 | 5 | 7 |
| 6 | Too Fat to Fish. Artie Lange with Anthony Bozza. Spiegel & Grau, $24.95 ISBN 978-0-385-52656-2 | 8 | 6 |
| 7 | A Bold Fresh Piece of Humanity. Bill O'Reilly. Broadway, $26 ISBN 978-0-767-92882-3 | 6 | 13 |
| 8 | Multiple Blessings. Jon & Kate Gosselin and Beth Carson. Zondervan, $19.99 ISBN 978-0-3102-8902-9 | 7 | 7 |
| 9 | Barefoot Contessa Back to Basics. Ina Garten. Clarkson Potter, $35 ISBN 978-1-4000-5435-0 | 10 | 8 |
| 10 | Why We Suck. Denis Leary. Viking, $26.95 ISBN 978-0-670-03160-3 | 13 | 5 |
| 11 | Guinness World Records 2009. Guinness Publishing, $28.95 ISBN 978-1-904994-37-4 | 9 | 12 |
| 12 | The Snowball. Alice Schroeder. Bantam, $35 ISBN 978-0-553-80509-3 | – | 11 |
| 13 | Breakthrough. Suzanne Somers. Crown, $25.95 ISBN 978-1-4000-5327-8 | – | 6 |
| 14 | Hot, Flat, and Crowded. Thomas L. Friedman. Farrar, Straus & Giroux, $27.95 ISBN 978-0-374-16685-4 | 14 | 15 |
| 15 | Do the Right Thing. Mike Huckabee. Sentinel, $25.95 ISBN 978-1-5952-3054-6 | 12 | 4 |
