Started in 2014 by Lucy Shelton Caswell, founder and curator of the Billy Ireland Cartoon Library & Museum, Jeff Smith, cartoonist and creator of the Bone comics series, and his wife Vijaya Iger, Cartoon Crossroads Columbus (CXC) is an international festival showcasing comics, editorial cartoons, newspaper comicstrips and animation, held annually in Columbus, Ohio. The comics and cartooning festival takes place partly on the campus of the Ohio State University (including working in conjunction with SolCon, OSU's black, brown and Latinx comics festival and student workshop), and the show's exhibition floor is located at the Columbus Metropolitan Library.

Over the course of the preceding week and the weekend of September 28-29, CXC offered keynote appearances by Hellboy creator Mike Mignola and a sold out appearance by Dog Man cartoonist Dav Pilkey. The show also offered access to the gallery and state of the art archival facility of the Billy Ireland Cartoon Library & Museum (including a reading room offering easy access to all manner of original comics art) as well programming and panels. Among the many artists appearing on the show floor at the library were such comics artists as Carta Monir, Ho Che Anderson, Tom Tomorrow, Katie Skelly, Lawrence Lindell, Bill Campbell, Nate Powell, Natasha Alterici, Derf Backderf, LaMorris Richmond, Mary Fleener, and Jiba Molei Anderson.